2n7l: Difference between revisions

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-'''Unreleased structure'''
-The entry 2n7l is ON HOLD  until Paper Publication
+==NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the covalent levosimendan analog i9==
+<StructureSection load='2n7l' size='340' side='right' caption='[[2n7l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Pineda Sanabria, S.E., Sykes, B.D., Robertson, I.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n7l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7L FirstGlance]. <br>
-Description: NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the covalent levosimendan analog i9
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J4:S-(2-{[(2,4-DIFLUOROBIPHENYL-4-YL)METHYL]AMINO}-2-OXOETHYL)-L-CYSTEINE'>4J4</scene></td></tr>
-[[Category: Sykes, B.D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7l OCA], [http://pdbe.org/2n7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7l RCSB], [http://www.ebi.ac.uk/pdbsum/2n7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7l ProSAT]</span></td></tr>
-[[Category: Pineda Sanabria, S.E]]
+</table>
-[[Category: Robertson, I.M]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:[http://omim.org/entry/611879 611879]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15542288</ref>   Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:[http://omim.org/entry/613243 613243]]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11385718</ref> <ref>PMID:16302972</ref> <ref>PMID:18572189</ref> <ref>PMID:19439414</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Robertson, I M]]
+[[Category: Sanabria, S E.Pineda]]
+[[Category: Sykes, B D]]
+[[Category: Calcium sensitizer]]
+[[Category: Contractile protein]]
+[[Category: Contraction regulation]]
+[[Category: Levosimendan]]
+[[Category: Troponin c]]