5hyu: Difference between revisions

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-'''Unreleased structure'''
-The entry 5hyu is ON HOLD  until Paper Publication
+==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein==
+<StructureSection load='5hyu' size='340' side='right' caption='[[5hyu]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hyu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYU FirstGlance]. <br>
-Description: Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyp|5hyp]], [[5hyt|5hyt]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyu OCA], [http://pdbe.org/5hyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyu RCSB], [http://www.ebi.ac.uk/pdbsum/5hyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyu ProSAT]</span></td></tr>
-[[Category: Bahn-Suh, A.J]]
+</table>
-[[Category: Buffalo, C.Z]]
+== Function ==
+[[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
+__TOC__
+</StructureSection>
+[[Category: Bahn-Suh, A J]]
+[[Category: Buffalo, C Z]]
 [[Category: Ghosh, P]]
+[[Category: Complement]]
+[[Category: Hypervariable antigen]]
+[[Category: Immune system]]
+[[Category: M protein]]
+[[Category: Streptococcus pyogene]]