Sandbox 130: Difference between revisions
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The active site contains key features for hydrolyzing carbapenems: | The active site contains key features for hydrolyzing carbapenems: | ||
Zinc ion 1(<scene name='37/372730/Chaina_cornflowerblue_zn1/1'>Zn1</scene>) is coordinated by three histidine residues:<scene name='37/372730/Chaina_cornflowerblue_zn1__/1'>H120, H122 and H189</scene>. | Zinc ion 1(<scene name='37/372730/Chaina_cornflowerblue_zn1/1'>Zn1</scene>) is coordinated by three histidine residues:<scene name='37/372730/Chaina_cornflowerblue_zn1__/1'>H120, H122 and H189</scene>. | ||
Zinc ion 2 (<scene name='37/372730/Symmetrical_4eyl_zn2/3'>Zn2</scene>) is coordinated by three residues: <scene name='37/372730/Symmetrical_4eyl_zn2_/1'>H250, C208, and D124</scene>. | Zinc ion 2 (<scene name='37/372730/Symmetrical_4eyl_zn2/3'>Zn2</scene>) is coordinated by three residues: <scene name='37/372730/Symmetrical_4eyl_zn2_/1'>H250, C208, and D124</scene>. | ||
3-D structure of the NDM-1 show two orthogonal views: side view of NDM-1 and looking into the active site. Zn1 and Zn2 are shown in cyan. The residues that coordinate with Zn1 are colored in orange and the residues that coordinate with Zn2 are colored in yellow. | |||