Sandbox 130: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==New Delhi Metallo-Beta-Lactamase== | --[[User:Allison Granberry|Allison Granberry]] 21:22, 18 July 2016 (IDT)==New Delhi Metallo-Beta-Lactamase== | ||
<Structure load='4eyl' size='350' frame='true' align='right' caption='Insert caption here' scene='NDN1' /> | <Structure load='4eyl' size='350' frame='true' align='right' caption='Insert caption here' scene='NDN1' /> | ||
Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role. | Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role. | ||