Sandbox 130: Difference between revisions
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<Structure load='4eyl' size='350' frame='true' align='right' caption='Insert caption here' scene='NDN1' /> | ==New Delhi Metallo-Beta-Lactamase== | ||
<Structure load='4eyl' size='350' frame='true' align='right' caption='Insert caption here' scene='NDN1' /> | |||
Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role. | Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role. | ||
Revision as of 21:04, 18 July 2016
New Delhi Metallo-Beta-LactamaseNew Delhi Metallo-Beta-Lactamase
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Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role.