Sandbox 130: Difference between revisions

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Revision as of 21:01, 18 July 2016 view source Allison Granberry (talk \| contribs) 742 edits No edit summary ← Older edit		Revision as of 21:04, 18 July 2016 view source Allison Granberry (talk \| contribs) 742 edits No edit summary Newer edit →
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	==New Delhi Metallo-Beta-Lactamase==		<Structure load='4eyl' size='350' frame='true' align='right' caption='Insert caption here' scene='NDN1' />==New Delhi Metallo-Beta-Lactamase==
	Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role.		Zn1 (coordinated by three histidine residues), acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex and acts to suppress the pKa of the hyrdolytic water to (~5-6) to facilitate it's nucleophilic role.