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Revision as of 20:54, 18 July 2016 view source Allison Granberry (talk \| contribs) 742 edits No edit summary ← Older edit		Revision as of 21:01, 18 July 2016 view source Allison Granberry (talk \| contribs) 742 edits No edit summary Newer edit →
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	==New Delhi Metallo-Beta-Lactamase==		==New Delhi Metallo-Beta-Lactamase==
			Zn1, coordinated by three histidine residues, acts as a major constituent of oxyanion hole to stabilize tetrahedral intermediate. It also acts as a Lewis acid for interaction with lactam carbonyl in Michaelis complex. Zn1 also acts to suppress the pka of the hydrolytic water to (~5-6) to facilitate it's nucleophillic role.