Protein phosphatase: Difference between revisions
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{{STRUCTURE_3k7v| PDB=3k7v | SIZE=400| SCENE= |right|CAPTION=Human PP2A catalytic (pink) and regulatory (grey) subunits complex with tumor-inducing toxin and sulfate [[3k7v]] }} | {{STRUCTURE_3k7v| PDB=3k7v | SIZE=400| SCENE= |right|CAPTION=Human PP2A catalytic (pink) and regulatory (grey) subunits complex with tumor-inducing toxin and sulfate [[3k7v]] }} | ||
'''Protein phosphatases''' (PP) | '''Protein phosphatases''' (PP) regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | ||
* '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | * '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | ||
* '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | * '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | ||
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== Disease == | == Disease == | ||
Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols<ref>PMID:23639323</ref>. Development of Alzheimer disease drugs could be based on restoration of PP2A activity<ref>PMID:21605044</ref>. | Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols<ref>PMID:23639323</ref>. Development of Alzheimer disease drugs could be based on restoration of PP2A activity<ref>PMID:21605044</ref>. | ||
== Structural highlights == | |||
Algal toxin binds at the surface pocket of the PP2A catalytic subunit which contains the Mn+2 ion cofactors<ref>PMID:19916524</ref>. | |||
== 3D Structures of protein phosphatase== | == 3D Structures of protein phosphatase== | ||