Protein phosphatase: Difference between revisions
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* '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | * '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | ||
* '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | * '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | ||
* '''PP2C''' are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways | * '''PP2C''' are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see [[ABA-regulated Protein Phosphatase 2C]].<br /> | ||
* '''PP4''' regulates a variety of cellular functions<ref>PMID: | * '''PP4''' regulates a variety of cellular functions<ref>PMID:25562660</ref>.<br /> | ||
* '''PP5''' is activated by lipids and is involved in signal transduction<ref>PMID: | * '''PP5''' is activated by lipids and is involved in signal transduction<ref>PMID:11137038</ref>. | ||
== Disease == | == Disease == | ||
Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols<ref>PMID: | Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols<ref>PMID:23639323</ref>. Development of Alzheimer disease drugs could be based on restoration of PP2A activity<ref>PMID:21605044</ref>. | ||
== 3D Structures of protein phosphatase== | == 3D Structures of protein phosphatase== | ||