Protein phosphatase: Difference between revisions
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'''Protein phosphatases''' (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | '''Protein phosphatases''' (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | ||
* '''PP1''' is a serine/threonine phosphatase.<br /> | * '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | ||
* '''PP2A''' targets proteins in the oncogenic signaling pathways. For PP2A see also [[HEAT Repeat]].<br /> | * '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | ||
* '''PP2C''' are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see [[ABA-regulated Protein Phosphatase 2C]].<br /> | * '''PP2C''' are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways<ref>PMID:8528769</ref>. For details see [[ABA-regulated Protein Phosphatase 2C]].<br /> | ||
* '''PP4''' regulates a variety of cellular functions.<br /> | * '''PP4''' regulates a variety of cellular functions<ref>PMID:8528769</ref>.<br /> | ||
* '''PP5''' is activated by lipids and is involved in signal transduction. | * '''PP5''' is activated by lipids and is involved in signal transduction<ref>PMID:8528769</ref>. | ||
== Disease == | |||
Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols<ref>PMID:8528769</ref>. Development of Alzheimer disease drugs could be based on restoration of PP2A activity<ref>PMID:21605044</ref>. | |||
== 3D Structures of protein phosphatase== | == 3D Structures of protein phosphatase== | ||
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== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:21, 18 July 2016
Protein phosphatases (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.
- PP1 is a serine/threonine phosphatase and is a key component of the insulin signaling pathway[1].
- PP2A targets proteins in the oncogenic signaling pathways[2]. For PP2A see also HEAT Repeat.
- PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways[3]. For details see ABA-regulated Protein Phosphatase 2C.
- PP4 regulates a variety of cellular functions[4].
- PP5 is activated by lipids and is involved in signal transduction[5].
DiseaseDisease
Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols[6]. Development of Alzheimer disease drugs could be based on restoration of PP2A activity[7].
3D Structures of protein phosphatase3D Structures of protein phosphatase
Updated on 18-July-2016
ReferencesReferences
- ↑ Ragolia L, Begum N. Protein phosphatase-1 and insulin action. Mol Cell Biochem. 1998 May;182(1-2):49-58. PMID:9609113
- ↑ Resjo S, Goransson O, Harndahl L, Zolnierowicz S, Manganiello V, Degerman E. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal. 2002 Mar;14(3):231-8. PMID:11812651
- ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
- ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
- ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
- ↑ White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995 Aug;5(4):521-7. PMID:8528769
- ↑ Rudrabhatla P, Pant HC. Role of protein phosphatase 2A in Alzheimer's disease. Curr Alzheimer Res. 2011 Sep;8(6):623-32. PMID:21605044