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==Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60== | |||
<StructureSection load='5jqh' size='340' side='right' caption='[[5jqh]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jqh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqh OCA], [http://pdbe.org/5jqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqh RCSB], [http://www.ebi.ac.uk/pdbsum/5jqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4]] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lysozyme]] | |||
[[Category: Ahn, S]] | |||
[[Category: Chatterjee, A]] | [[Category: Chatterjee, A]] | ||
[[Category: | [[Category: Costa, T]] | ||
[[Category: | [[Category: Kahsai, A W]] | ||
[[Category: Kim, T H]] | |||
[[Category: Kobilka, B K]] | |||
[[Category: Kruse, A C]] | |||
[[Category: Lefkowitz, R J]] | |||
[[Category: Manglik, A]] | |||
[[Category: Masoudi, A]] | [[Category: Masoudi, A]] | ||
[[Category: Pani, B]] | |||
[[Category: Pardon, E]] | [[Category: Pardon, E]] | ||
[[Category: | [[Category: Prosser, R S]] | ||
[[Category: | [[Category: Staus, D P]] | ||
[[Category: Steyaert, J]] | [[Category: Steyaert, J]] | ||
[[Category: | [[Category: Strachan, R T]] | ||
[[Category: | [[Category: Weis, W I]] | ||
[[Category: | [[Category: Wingler, L M]] | ||
[[Category: | [[Category: Allostery]] | ||
[[Category: | [[Category: Gpcr]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Hydrolase-inhibitor complex]] | ||
[[Category: | [[Category: Nanobody]] | ||
[[Category: | [[Category: Signaling]] | ||
[[Category: | [[Category: Signaling protein]] | ||
Revision as of 14:47, 14 July 2016
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Structural highlights
Function[ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1] References
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