5l5k: Difference between revisions

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'''Unreleased structure'''


The entry 5l5k is ON HOLD until Paper Publication
==Plexin A4 full extracellular region, domains 1 to 10, data to 7.5 angstrom, spacegroup P4(1)==
 
<StructureSection load='5l5k' size='340' side='right' caption='[[5l5k]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5l5k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L5K FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l5k OCA], [http://pdbe.org/5l5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l5k RCSB], [http://www.ebi.ac.uk/pdbsum/5l5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l5k ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PLXA4_MOUSE PLXA4_MOUSE]] Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:12591607</ref> <ref>PMID:18262512</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Coles, C H]]
[[Category: Gilbert, R J.C]]
[[Category: Janssen, B J.C]]
[[Category: Jones, E Y]]
[[Category: Kaufmann, R]]
[[Category: Kong, Y]]
[[Category: Malinauskas, T]]
[[Category: Ni, T]]
[[Category: Padilla-Parra, S]]
[[Category: Pasterkamp, R J]]
[[Category: Vangoor, V R]]
[[Category: Axon guidance]]
[[Category: Receptor]]
[[Category: Signaling]]
[[Category: Signaling protein]]

Revision as of 21:05, 13 July 2016

Plexin A4 full extracellular region, domains 1 to 10, data to 7.5 angstrom, spacegroup P4(1)Plexin A4 full extracellular region, domains 1 to 10, data to 7.5 angstrom, spacegroup P4(1)

Structural highlights

5l5k is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PLXA4_MOUSE] Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.[1] [2]

References

  1. ↑ Suto F, Murakami Y, Nakamura F, Goshima Y, Fujisawa H. Identification and characterization of a novel mouse plexin, plexin-A4. Mech Dev. 2003 Mar;120(3):385-96. PMID:12591607
  2. ↑ Waimey KE, Huang PH, Chen M, Cheng HJ. Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors. Dev Biol. 2008 Mar 15;315(2):448-58. doi: 10.1016/j.ydbio.2008.01.002. Epub 2008 , Jan 16. PMID:18262512 doi:http://dx.doi.org/10.1016/j.ydbio.2008.01.002

5l5k, resolution 7.50Å

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OCA
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