5fi9: Difference between revisions
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==Closed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPA== | |||
<StructureSection load='5fi9' size='340' side='right' caption='[[5fi9]], [[Resolution|resolution]] 2.54Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fi9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NT8:(1-AZANYL-1-PHOSPHONO-DECYL)PHOSPHONIC+ACID'>NT8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fib|5fib]], [[5fic|5fic]], [[5hqn|5hqn]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphingomyelin_phosphodiesterase Sphingomyelin phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.12 3.1.4.12] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi9 OCA], [http://pdbe.org/5fi9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ASM_MOUSE ASM_MOUSE]] Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.[UniProtKB:P17405] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Sphingomyelin phosphodiesterase]] | |||
[[Category: Gorelik, A]] | |||
[[Category: Heinz, L X]] | |||
[[Category: Illes, K]] | |||
[[Category: Nagar, B]] | |||
[[Category: Superti-Furga, G]] | |||
[[Category: Asm]] | |||
[[Category: Asmase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Smpd1]] | |||
[[Category: Sphingomyelinase]] | |||
Revision as of 20:59, 13 July 2016
Closed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPAClosed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPA
Structural highlights
Function[ASM_MOUSE] Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.[UniProtKB:P17405] |
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