1jsm: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1jsi|1JSI]], [[1jsh|1JSH]], [[1jsd|1JSD]], [[1jsn|1JSN]], [[1jso|1JSO]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsm OCA], [http://www.ebi.ac.uk/pdbsum/1jsm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jsm RCSB]</span> | |||
}} | }} | ||
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[[Category: Stevens, D J.]] | [[Category: Stevens, D J.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
[[Category: fusion protein]] | [[Category: fusion protein]] | ||
[[Category: influenza]] | [[Category: influenza]] | ||
[[Category: receptor complex]] | [[Category: receptor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:23 2008'' | ||
Revision as of 21:38, 30 March 2008
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| , resolution 1.9Å | |||||||
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| Ligands: | |||||||
| Related: | 1JSI, 1JSH, 1JSD, 1JSN, 1JSO
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF H5 AVIAN HAEMAGGLUTININ
OverviewOverview
There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
About this StructureAbout this Structure
1JSM is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.
ReferenceReference
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:11867515
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