5cht: Difference between revisions
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==Crystal structure of USP18== | |||
<StructureSection load='5cht' size='340' side='right' caption='[[5cht]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cht]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cht OCA], [http://pdbe.org/5cht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cht RCSB], [http://www.ebi.ac.uk/pdbsum/5cht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cht ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBP18_MOUSE UBP18_MOUSE]] Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Basters, A]] | |||
[[Category: Fritz, G]] | [[Category: Fritz, G]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: Interferon]] | |||
[[Category: Isg15]] | |||
[[Category: Ubiquitin-specific protease]] | |||
Revision as of 13:20, 13 July 2016
Crystal structure of USP18Crystal structure of USP18
Structural highlights
Function[UBP18_MOUSE] Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (By similarity). |
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