5bpv: Difference between revisions

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-'''Unreleased structure'''
-The entry 5bpv is ON HOLD  until Paper Publication
+==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A==
+<StructureSection load='5bpv' size='340' side='right' caption='[[5bpv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-Authors: Fadda, V., Cannas, V., Zinzula, L., Distinto, S., Daino, G.L., Bianco, G., Corona, A., Esposito, F., Alcaro, S., Maccioni, E., Tramontano, E., Taylor, G.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPV FirstGlance]. <br>
-Description: Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [http://pdbe.org/5bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [http://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Zinzula, L]]
+== Function ==
-[[Category: Esposito, F]]
+[[http://www.uniprot.org/uniprot/VP35_EBOZ5 VP35_EBOZ5]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
-[[Category: Tramontano, E]]
+__TOC__
-[[Category: Maccioni, E]]
+</StructureSection>
+[[Category: Alcaro, S]]
 [[Category: Bianco, G]]
-[[Category: Daino, G.L]]
+[[Category: Cannas, V]]
 [[Category: Corona, A]]
-[[Category: Cannas, V]]
+[[Category: Daino, G L]]
-[[Category: Alcaro, S]]
 [[Category: Distinto, S]]
+[[Category: Esposito, F]]
 [[Category: Fadda, V]]
-[[Category: Taylor, G.L]]
+[[Category: Maccioni, E]]
+[[Category: Taylor, G L]]
+[[Category: Tramontano, E]]
+[[Category: Zinzula, L]]
+[[Category: Interferon inhibitor]]
+[[Category: Polymerase cofactor]]
+[[Category: Viral protein]]