5a4w: Difference between revisions

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'''Unreleased structure'''


The entry 5a4w is ON HOLD  until Paper Publication
==AtGSTF2 from Arabidopsis thaliana in complex with quercetrin==
 
<StructureSection load='5a4w' size='340' side='right' caption='[[5a4w]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
Authors: Ahmad, L., Rylott, E., Bruce, N.C., Edwards, R., Grogan, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5a4w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4W FirstGlance]. <br>
Description: AtGSTF2 from Arabidopsis thaliana in complex with quercetrin
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=QCT:2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-OXO-4H-CHROMEN-3-YL+6-DEOXY-ALPHA-L-MANNOPYRANOSIDE'>QCT</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a4u|5a4u]], [[5a4v|5a4v]], [[5a4y|5a4y]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4w OCA], [http://pdbe.org/5a4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4w RCSB], [http://www.ebi.ac.uk/pdbsum/5a4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4w ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GSTF2_ARATH GSTF2_ARATH]] Binds auxin, endogenous flavonoids and the phytoalexin camalexin and may be involved in regulating the binding and transport of small bioactive natural products and defense-related compounds during plant stress. Binds a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). Acts as glutathione peroxidase on cumene hydroperoxide, linoleic acid-13-hydroperoxide and trans-stilbene oxide, but not trans-cinnamic acid or IAA-CoA.<ref>PMID:12090627</ref> <ref>PMID:21631432</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Glutathione transferase]]
[[Category: Ahmad, L]]
[[Category: Ahmad, L]]
[[Category: Bruce, N.C]]
[[Category: Bruce, N C]]
[[Category: Edwards, R]]
[[Category: Edwards, R]]
[[Category: Grogan, G]]
[[Category: Rylott, E]]
[[Category: Rylott, E]]
[[Category: Grogan, G]]
[[Category: Arabidopsis]]
[[Category: Glutathione-s-transferase]]
[[Category: Gst]]
[[Category: Plant]]
[[Category: Transferase]]

Revision as of 13:16, 13 July 2016

AtGSTF2 from Arabidopsis thaliana in complex with quercetrinAtGSTF2 from Arabidopsis thaliana in complex with quercetrin

Structural highlights

5a4w is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Glutathione transferase, with EC number 2.5.1.18
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GSTF2_ARATH] Binds auxin, endogenous flavonoids and the phytoalexin camalexin and may be involved in regulating the binding and transport of small bioactive natural products and defense-related compounds during plant stress. Binds a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). Acts as glutathione peroxidase on cumene hydroperoxide, linoleic acid-13-hydroperoxide and trans-stilbene oxide, but not trans-cinnamic acid or IAA-CoA.[1] [2]

References

  1. ↑ Wagner U, Edwards R, Dixon DP, Mauch F. Probing the diversity of the Arabidopsis glutathione S-transferase gene family. Plant Mol Biol. 2002 Jul;49(5):515-32. PMID:12090627
  2. ↑ Dixon DP, Sellars JD, Edwards R. The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands. Biochem J. 2011 Aug 15;438(1):63-70. doi: 10.1042/BJ20101884. PMID:21631432 doi:http://dx.doi.org/10.1042/BJ20101884

5a4w, resolution 2.25Å

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