4ydp: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ydp is ON HOLD  until Paper Publication
+==Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.==
+<StructureSection load='4ydp' size='340' side='right' caption='[[4ydp]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Grishkovskaya, I., Onipe, A., Kontaxis, G., Djinovic-Carugo, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ydp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDP FirstGlance]. <br>
-Description: Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydp OCA], [http://pdbe.org/4ydp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ydp RCSB], [http://www.ebi.ac.uk/pdbsum/4ydp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydp ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN]] Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:[http://omim.org/entry/601493 601493]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14662268</ref> <ref>PMID:14660611</ref>   Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:[http://omim.org/entry/601493 601493]]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.  Defects in LDB3 are the cause of myopathy myofibrillar type 4 (MFM4) [MIM:[http://omim.org/entry/609452 609452]]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
+== Function ==
+[[http://www.uniprot.org/uniprot/LDB3_HUMAN LDB3_HUMAN]] May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.[:]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Djinovic-Carugo, K]]
+[[Category: Grishkovskaya, I]]
 [[Category: Kontaxis, G]]
-[[Category: Grishkovskaya, I]]
 [[Category: Onipe, A]]
+[[Category: Myotilin]]
+[[Category: Sarcomere]]
+[[Category: Striated muscle z-disc]]
+[[Category: Structural protein]]
+[[Category: Zasp/ldb3]]