Plasmepsin: Difference between revisions
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{{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin dimer witn Zn+2 ions (grey), [[3fns]] }} | {{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin dimer witn Zn+2 ions (grey), [[3fns]] }} | ||
[[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite | == Function == | ||
[[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and '''Histo-Aspartic Protease (HAP)'''. | |||
*'''Proplasmepsin II''' exhibits a large shift between its domains which renders the protease inactive. | |||
==Relevance == | |||
Plm is a potential target for anti-malaria drugs<ref>PMID:25719272</ref>. | |||
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**[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br /> | **[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br /> | ||
**[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br /> | **[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br /> | ||
*Plasmepsin IV | |||
**[[2anl]] – Plm IV + statine derivative – ''Plasmodium malariae''<br /> | |||
**[[1ls5]] - PfPlm IV + pepstatin derivative<br /> | |||
*Proplasmepsin II | *Proplasmepsin II | ||
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**[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br /> | **[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br /> | ||
**[[1qs8]] - PvPlm + pepstatin derivative<br /> | **[[1qs8]] - PvPlm + pepstatin derivative<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||