Phospholipase A2: Difference between revisions
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*'''PLA2 group XV''' is located in the endocytic system and may be involved in CD1d function<ref>PMID:23943550</ref>. <br /> | *'''PLA2 group XV''' is located in the endocytic system and may be involved in CD1d function<ref>PMID:23943550</ref>. <br /> | ||
*'''PLA2 group XVI''' is adipose-specific<ref>PMID:18614531</ref>. <br /> | *'''PLA2 group XVI''' is adipose-specific<ref>PMID:18614531</ref>. <br /> | ||
*'''Lipoprotein-associated phospholipase A2''' or '''platelet-activating factor acetylhydrolase''' (Lp-PLA2) degrades platelet-activating factor and oxidized phospholipids into inactive metabolites. Platelet-activating factor is a potent phospholipid activator and mediator of inflammation, platelet aggregation and other leukocyte functions. | *'''Lipoprotein-associated phospholipase A2''' or '''platelet-activating factor acetylhydrolase''' (Lp-PLA2) degrades platelet-activating factor and oxidized phospholipids into inactive metabolites. Platelet-activating factor is a potent phospholipid activator and mediator of inflammation, platelet aggregation and other leukocyte functions<ref>PMID:7700381</ref>. <br />. | ||
*'''Bothropstoxin (BTX)''' is PLA2 from the snake ''Bothrops jararacussu''.<br /> | *'''Bothropstoxin (BTX)''' is PLA2 from the snake ''Bothrops jararacussu''.<br /> | ||
*'''Piratoxin (PTX)''' is PLA2 from the snake ''Bothrops piraña''.<br /> | *'''Piratoxin (PTX)''' is PLA2 from the snake ''Bothrops piraña''.<br /> | ||
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== Relevance == | == Relevance == | ||
PLA2 serve as pharmacological targets for therapeutical treatment of diseases like atherosclerosis, immune disorders, cardiovascular diseases and cancer<ref>PMID:24907600</ref>. | PLA2 serve as pharmacological targets for therapeutical treatment of diseases like atherosclerosis, immune disorders, cardiovascular diseases and cancer<ref>PMID:24907600</ref>. Reduced Lp-PLA2 activity is observed in patients with severe sepsis. There is association between the level of Lp-PLA2 in plasma and the risk of future cardiovascular events<ref>PMID:19272461</ref>. | ||
== Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione == | == Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione == | ||