Phosphoenolpyruvate carboxykinase: Difference between revisions

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{{STRUCTURE_2olr|  PDB=2olr  | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green)  [[2olr]] }}


<StructureSection load='1khf' size='350' side='right' caption='GTP-driven E. coli PEPCK complex with PEP (stick model), ethanediol, Na+ and Mn+2 ions (green) (PDB entry [[1khf]])' scene=''>
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== Function ==
'''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>.  PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>.  There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.
'''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>.  PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>.  There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.


== Structural highlights ==
''E. coli'' GTP-driven PEPCK active site is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>.
</StructureSection>
== 3D Structures of PEPCK ==
== 3D Structures of PEPCK ==


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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman