Phosphoenolpyruvate carboxykinase: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
Line 1: | Line 1: | ||
<StructureSection load='1khf' size='350' side='right' caption='GTP-driven E. coli PEPCK complex with PEP (stick model), ethanediol, Na+ and Mn+2 ions (green) (PDB entry [[1khf]])' scene=''> | |||
__TOC__ | |||
== Function == | |||
'''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>. PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | '''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO<sub>2</sub>. PEPCK is part of the gluconeogenesis pathway<ref>PMID:9242918</ref>. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | ||
== Structural highlights == | |||
''E. coli'' GTP-driven PEPCK active site is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>. | |||
</StructureSection> | |||
== 3D Structures of PEPCK == | == 3D Structures of PEPCK == | ||