User:Eric Martz/5eon: Difference between revisions
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The [[biological unit]] of [[5eon]] is a crystallographic structure of 6 alpha helices assembled into a fiber with a hydrophobic core<ref name="5eon">PMID: 27192036</ref>. The individual peptides are synthetic and were designed to assemble in this manner, with a hydrophotic core rich in phenylalanine. The crystal structure has a [[resolution]] of 1.7 Å (very good), and an [[Rfree]] of 0.22, which is average for this resolution, indicating that the model is reliable. | The [[biological unit]] of [[5eon]] is a crystallographic structure of 6 alpha helices assembled into a fiber with a hydrophobic core<ref name="5eon">PMID: 27192036</ref>. The individual peptides are synthetic and were designed to assemble in this manner, with a hydrophotic core rich in phenylalanine. The crystal structure has a [[resolution]] of 1.7 Å (very good), and an [[Rfree]] of 0.22, which is average for this resolution, indicating that the model is reliable. | ||
The <scene name='73/733958/Hexamer_of_5eon/3'>aromatic rings of Phe pack in the core</scene>. | The <scene name='73/733958/Hexamer_of_5eon/3'>aromatic rings of Phe pack in the core</scene>. The Phe rings (<font color="#808080">'''dark gray'''</font>) are surrounded by <scene name='73/733958/Hexamer_of_5eon/4'>hydrophobic sidechains of Ile</scene> (<font color="#a0a0a0">'''light gray'''</font>). | ||
The charges form <scene name='73/733958/Hexamer_of_5eon/2'>helices of opposite charge</scene> on the surface, reminiscent of [[User:Ke Xiao/Geobacter pilus models|Xiao's theoretical model of the ''Geobacter sulfurreducens'' pilus]]. | The charges form <scene name='73/733958/Hexamer_of_5eon/2'>helices of opposite charge</scene> on the surface, reminiscent of [[User:Ke Xiao/Geobacter pilus models|Xiao's theoretical model of the ''Geobacter sulfurreducens'' pilus]]. | ||