5ihl: Difference between revisions

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'''Unreleased structure'''


The entry 5ihl is ON HOLD  until Paper Publication
==STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB==
 
<StructureSection load='5ihl' size='340' side='right' caption='[[5ihl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: Sheriff, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ihl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IHL FirstGlance]. <br>
Description: STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihl OCA], [http://pdbe.org/5ihl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihl RCSB], [http://www.ebi.ac.uk/pdbsum/5ihl PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Sheriff, S]]
[[Category: Sheriff, S]]
[[Category: Antitumor]]
[[Category: Cell surface receptor]]
[[Category: Domain antibody]]
[[Category: Immune system-signaling protein complex]]
[[Category: Protein/protein interaction]]

Revision as of 09:10, 2 June 2016

STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DABSTRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB

Structural highlights

5ihl is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Disease

[TNR5_HUMAN] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:606843]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.[1]

Function

[TNR5_HUMAN] Receptor for TNFSF5/CD40LG.

References

  1. ↑ Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9. PMID:11675497 doi:10.1073/pnas.221456898

5ihl, resolution 3.30Å

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