5ewa: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ewa is ON HOLD  until Paper Publication
+==Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26==
+<StructureSection load='5ewa' size='340' side='right' caption='[[5ewa]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Kosmopoulou, M., Hinchliffe, P., Spencer, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ewa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EWA FirstGlance]. <br>
-Description: Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9BZ:(3~{R},5~{R},7~{A}~{S})-2,2-DIMETHYL-5-(SULFANYLMETHYL)-3,5,7,7~{A}-TETRAHYDRO-[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>9BZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ewa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewa OCA], [http://pdbe.org/5ewa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ewa RCSB], [http://www.ebi.ac.uk/pdbsum/5ewa PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
+__TOC__
+</StructureSection>
+[[Category: Beta-lactamase]]
+[[Category: Hinchliffe, P]]
+[[Category: Kosmopoulou, M]]
 [[Category: Spencer, J]]
-[[Category: Kosmopoulou, M]]
+[[Category: Antibiotic resistance]]
-[[Category: Hinchliffe, P]]
+[[Category: Carbapenemase]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]