5fxu: Difference between revisions

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-'''Unreleased structure'''
-The entry 5fxu is ON HOLD  until Paper Publication
+==Crystal Structure of Puumala virus Gn glycoprotein ectodomain==
+<StructureSection load='5fxu' size='340' side='right' caption='[[5fxu]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fxu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FXU FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxu OCA], [http://pdbe.org/5fxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fxu RCSB], [http://www.ebi.ac.uk/pdbsum/5fxu PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses.
-Authors: Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O.G., Huiskonen, J.T., Bowden, T.A.
+A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403<ref>PMID:27117403</ref>
-Description: Crystal Structure of Puumala virus Gn glycoprotein ectodomain
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5fxu" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bowden, T A]]
+[[Category: Harlos, K]]
+[[Category: Hepojoki, J]]
+[[Category: Huiskonen, J T]]
 [[Category: Li, S]]
+[[Category: Pybus, O G]]
 [[Category: Raghwani, J]]
-[[Category: Pybus, O.G]]
+[[Category: Rissanen, I]]
 [[Category: Zeltina, A]]
-[[Category: Rissanen, I]]
+[[Category: Bunyavirus]]
-[[Category: Bowden, T.A]]
+[[Category: Glycoprotein]]
-[[Category: Huiskonen, J.T]]
+[[Category: Gn]]
-[[Category: Harlos, K]]
+[[Category: Hantavirus]]
-[[Category: Hepojoki, J]]
+[[Category: Puumala virus]]
+[[Category: Viral glycoprotein]]
+[[Category: Viral protein]]