Nuclear transcription factor Y: Difference between revisions

Revision as of 11:43, 16 May 2016

Function

Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence^[1]. See details in NF-Y Transcription Factor.

Relevance

NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer^[2].

Human nuclear transcription factor Y subunit β (grey) and subunit γ(green) (PDB code 1n1j)

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3D Structures of nuclear transcription factor Y3D Structures of nuclear transcription factor Y

Updated on 16-May-2016

1n1j, 4csr – hNFY β+γ subunits - human
4awl – hNFY α+β+γ subunits + promoter DNA

ReferencesReferences

↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081
↑ Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081

[2] Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180

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@@ Line 8: / Line 8: @@
 == Relevance ==
-NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer.
+NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer<ref>PMID:9095180</ref>.
 </StructureSection>