NF-kB

Function NF-kB or Nuclear Factor NF-kappa is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. I-κ-B-α is an inhibitor of NF-kB. There are 5 proteins in the NF-kB family: NF-kB1 (synthesized as p105 and processed to p50) NF-kB2 (synthesized as p100 and processed to p52) RelA (or p65 subunit of NF-kB) RelB cRel. Relevance NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents. NF-kB is a critical link between inflammation and cancer.

spinqualitylabelsall models Structure of mouse NF-kB1 p50 complex with DNA (PDB entry 1nfk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of NF-kappaB3D structures of NF-kappaB

Updated on 15-May-2016

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• RelA (p65)
  • 1bft, 1my5 – mRelA dimerization domain – mouse
    
  • 1my7 – mRelA dimerization domain (mutant)
    
  • 1ram, 2ram – mRelA residues 19-291 + DNA
    
  • 1k3z, 1oy3 – mRelA dimerization domain + I-κ-B-α
    
• NF-kB1 (p50)
  • 1svc – hp50 + DNA - human - NMR
    
  • 1nfk – mp50 + DNA
    
  • 1bfs – mp50 dimerization domain
    
  • 1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42 – mp50 dimerization domain (mutant)
    
• NF-kB1 (p105)
  • 2dbf – hp105 death domain
    
  • 1ooa – mp105 + RNA
    
• NF-kB1 + RelA
  • 1nfi – hp50 + RelA + I-κ-B-α
    
  • 1ikn – mp50 + RelA + I-κ-B-α
    
  • 1vkx, 1le5, 1le9, 1lei – mp50 + RelA + DNA
    
  • 2i9t – mp105 + RelA + DNA
    
  • 2v2t – mp50 + RelB + DNA
    
  • 2o61 – hp105 RHR domain + RelA + DNA
    
  • 3gut – hp105 + RelA + DNA
    
  • 3jv4 – hp105 dimerization domain + RelB dimerization domain