5ebw: Difference between revisions

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'''Unreleased structure'''


The entry 5ebw is ON HOLD  until Paper Publication
==KcsA with G77ester mutation==
 
<StructureSection load='5ebw' size='340' side='right' caption='[[5ebw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
Authors: Matulef, K., Valiyaveetil, F.I.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ebw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EBW FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene></td></tr>
[[Category: Valiyaveetil, F.I]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ebl|5ebl]], [[5ebm|5ebm]], [[5ec1|5ec1]], [[5ec2|5ec2]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ebw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ebw OCA], [http://pdbe.org/5ebw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ebw RCSB], [http://www.ebi.ac.uk/pdbsum/5ebw PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Matulef, K]]
[[Category: Matulef, K]]
[[Category: Valiyaveetil, F I]]
[[Category: Alpha-helical]]
[[Category: Channel]]
[[Category: Fab]]
[[Category: Membrane protein]]

Revision as of 21:43, 12 May 2016

KcsA with G77ester mutationKcsA with G77ester mutation

Structural highlights

5ebw is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]

References

  1. ↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

5ebw, resolution 2.30Å

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