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==Crystal structure of DAAO(Y228L/R283G) variant (R-2-phenylpyrrolidine binding form)== | |||
<StructureSection load='4yjh' size='340' side='right' caption='[[4yjh]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yjh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YJH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=96B:(2R)-2-PHENYLPYRROLIDINE'>96B</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yjg|4yjg]], [[4yjf|4yjf]], [[4yjd|4yjd]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yjh OCA], [http://pdbe.org/4yjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yjh RCSB], [http://www.ebi.ac.uk/pdbsum/4yjh PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: D-amino-acid oxidase]] | |||
[[Category: Asano, Y]] | [[Category: Asano, Y]] | ||
[[Category: Ishitsubo, E]] | |||
[[Category: Kawahara, N]] | |||
[[Category: Nakano, S]] | [[Category: Nakano, S]] | ||
[[Category: Tokiwa, H]] | [[Category: Tokiwa, H]] | ||
[[Category: | [[Category: Yasukawa, K]] | ||
[[Category: | [[Category: Amine oxidase]] | ||
[[Category: Oxidoreductase]] | |||
[[Category: R-2-phenylpyrrolidine binding form]] | |||
[[Category: Variant of d-amino acid oxidase]] | |||
Revision as of 07:02, 12 May 2016
Crystal structure of DAAO(Y228L/R283G) variant (R-2-phenylpyrrolidine binding form)Crystal structure of DAAO(Y228L/R283G) variant (R-2-phenylpyrrolidine binding form)
Structural highlights
Function[OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. |
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