4yjf: Difference between revisions

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-'''Unreleased structure'''
-The entry 4yjf is ON HOLD  until Paper Publication
+==Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)==
+<StructureSection load='4yjf' size='340' side='right' caption='[[4yjf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Nakano, S., Yasukawa, K., Kawahara, N., Ishitsubo, E., Tokiwa, H., Asano, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yjf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YJF FirstGlance]. <br>
-Description: Crystal structure of DAAO(Y228L/R283G) variant (S-methylbenzylamine binding form)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=98B:(1S)-1-PHENYLETHANAMINE'>98B</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yjh|4yjh]], [[4yjg|4yjg]], [[4yjd|4yjd]]</td></tr>
-[[Category: Yasukawa, K]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yjf OCA], [http://pdbe.org/4yjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yjf RCSB], [http://www.ebi.ac.uk/pdbsum/4yjf PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
+__TOC__
+</StructureSection>
+[[Category: D-amino-acid oxidase]]
 [[Category: Asano, Y]]
+[[Category: Ishitsubo, E]]
+[[Category: Kawahara, N]]
 [[Category: Nakano, S]]
 [[Category: Tokiwa, H]]
-[[Category: Kawahara, N]]
+[[Category: Yasukawa, K]]
-[[Category: Ishitsubo, E]]
+[[Category: Amine oxidase]]
+[[Category: Oxidoreductase]]
+[[Category: S-methylbenzylamine binding form]]
+[[Category: Variant of d-amino acid oxidase]]