5ijf: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ijf is ON HOLD
+==Crystal structure of Human Serum Albumin in the presence of 0.5 mM zinc at pH 9.0==
+<StructureSection load='5ijf' size='340' side='right' caption='[[5ijf]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Handing, K.B., Shabalin, I.G., Cooper, D.R., Grabowski, M., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ijf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IJF FirstGlance]. <br>
-Description: Crystal structure of Human Serum Albumin in the presence of 0.5 mM zinc at pH 9.0
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iih|5iih]], [[5hoz|5hoz]], [[5iiu|5iiu]], [[5iix|5iix]], [[5ij5|5ij5]], [[5ije|5ije]]</td></tr>
-[[Category: Almo, S.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijf OCA], [http://pdbe.org/5ijf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ijf RCSB], [http://www.ebi.ac.uk/pdbsum/5ijf PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Almo, S C]]
+[[Category: Cooper, D R]]
+[[Category: Grabowski, M]]
+[[Category: Handing, K B]]
 [[Category: Minor, W]]
-[[Category: Handing, K.B]]
+[[Category: Structural genomic]]
-[[Category: Shabalin, I.G]]
+[[Category: Shabalin, I G]]
-[[Category: New York Structural Genomics Research Consortium (Nysgrc)]]
+[[Category: Nysgrc]]
-[[Category: Grabowski, M]]
+[[Category: Psi-biology]]
-[[Category: Cooper, D.R]]
+[[Category: Transport protein]]