Neurexin

<StructureSection load='2xb6' size='350' side='right' caption='Rat neurexin 1α LNS domainpink, yellow) complex with neuroligin-4 cholinesterase domain and Ca+2 ion (PDB entry 2xb6)' scene=>

FunctionFunction

Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.

See: Neurodevelopmental Disorders
Neuroligin-Neurexin Interaction

RelevanceRelevance

NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases.

3D Structures of Neurexin3D Structures of Neurexin

08-May-2016

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• Neurexin
  • 3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
    
  • 3bod, 3bop - mNRXN-1α LNS domain
    
  • 3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
    
  • 2r16 - rNRXN-1α LNS domain+Ca
    
  • 1c4r - rNRXN-1α LNS domain
    
  • 3mw4 - mNRXN-1α LNS domain
    
  • 2h0b - bNRXN-1α LNS2 domain – bovine
    
  • 3asi - bNRXN-1α LNS5-EGF3-LNS6 domains
    
  • 3poy - bNRXN-1α LNS2-LNS6 domains (mutant)
    
  • 3qcw, 3r05 - bNRXN-1α LNS1-LNS6 domains (mutant)
    
  • 2r1d - rNRXN-1β LNS/LG domain
• NRXN+Neuroligin
  • 2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
    
  • 3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
    
  • 3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
    
  • 3vkf - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain