Mitogen-activated protein kinase: Difference between revisions
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== Function == | == Function == | ||
[[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>. <br /> | [[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>. <br /> | ||
* '''MAPK1''' and '''MAPK3''' are activated in response to growth factors. | * '''MAPK1''' or '''ERK2''' and '''MAPK3''' are activated in response to growth factors. For '''MAPK1''' representations see [[Michael Roberts/BIOL115/ERK2]].<br /> | ||
* '''MAPK6''' is activated by phorbol esters.<br /> | * '''MAPK6''' is activated by phorbol esters.<br /> | ||
* '''MAPK7''' is activated by stress stimuli.<br /> | * '''MAPK7''' is activated by stress stimuli.<br /> | ||