XPD Helicase (3CRV): Difference between revisions

The structure of the subunit XPD helicase contains one main domain, a DNA interaction interface, and two motifs, one of which performs the function of unwinding the DNA strand. Residues 7-283 form the Helicase ATP binding domain(<scene name='72/728075/Binding_domain/5'>Helicase-ATP Domain</scene>), where ATP itself binds at residues 42-49, (<scene name='72/728075/Nucleotide_binding/3'>ATP Binding</scene>). Interaction with the gene MMS19 is mediated by region consisting of residues 438-637. Residues 234-237 form the motif which is the DEAH box (pertains to a family of proteins that have this region in order to unwind DNA) of this transcription factor which is where the unwinding of DNA is performed. A second motif located at residues 682-695 is where the nuclear localization signal is located. Iron Sulfur bonding residues consist of C116, C134, C155, and C160. Features of Cockayne Syndrome and Xeroderma pigmentosum  have been associated with point mutation G602D, and point mutation L461V is associated with TTD1 <ref>DOI 10.1093/nar/gku989 </ref>.