XPD Helicase (3CRV): Difference between revisions
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== Structure Description == | == Structure Description == | ||
Residues 7-283 form the Helicase ATP binding domain. Interaction with the gene MMS19 is mediated by region consisting of residues 438-637. Residues 234-237 form the motif which is the DEAH box of this transcription factor. A second motif located at residues 682-695 is where the nuclear localization signal is located. Iron Sulfur bonding residues consist of C116, C134, C155, and C160. <ref>DOI 10.1093/nar/gku989 </ref>. | Residues 7-283 form the Helicase ATP binding domain. Interaction with the gene MMS19 is mediated by region consisting of residues 438-637. Residues 234-237 form the motif which is the DEAH box of this transcription factor. A second motif located at residues 682-695 is where the nuclear localization signal is located. Iron Sulfur bonding residues consist of C116, C134, C155, and C160. Features of Cockayne Syndrome and Xeroderma pigmentosum have been associated with point mutation G602D, and point mutation L461V is associated with TTD1 <ref>DOI 10.1093/nar/gku989 </ref>. | ||
== Structural highlights == | == Structural highlights == | ||