Metabotropic glutamate receptor: Difference between revisions
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<Structure load=' | <Structure load='1ewk' size='350' side='right' caption='Structure of the binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate and gadolinium ions ([[1isr]])' scene=' '/> | ||
[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | [[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | ||
Revision as of 12:05, 21 April 2016
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Metabotropic glutamate receptors are glutamate receptors that activate ion channels indirectly through a signaling cascade involving G proteins[1]. They are members of the large class of seven-transmembrane domain receptors, the G protein-coupled receptors. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also Ligand Binding N-Terminal of Metabotropic Glutamate Receptors.
- Metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 belong to group I and activate phospholipase C.
- Metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3 belong to group II and inhibit the cyclic AMP cascade.
- Metabotropic glutamate receptor 7 belongs to group III and inhibits adenylate cyclase activity.
Articles in Proteopedia concerning Toll-like Receptors include:
3D structures of metabotropic glutamate receptor3D structures of metabotropic glutamate receptor
Updated on 21-April-2016
See AlsoSee Also
Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease
ReferencesReferences
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451