Major histocompatibility complex: Difference between revisions
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<StructureSection load='2hla' size='350' side='right' caption='Human MHC class I complex (grey) with β 2-microglobulin (green), [[2hla]]' scene=''> | <StructureSection load='2hla' size='350' side='right' caption='Human MHC class I complex (grey) with β 2-microglobulin (green), [[2hla]]' scene=''> | ||
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
* '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins. For more details see <br /> | * '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | ||
*[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> | *[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> | ||
*[[MR1 Binds Vitamin Metabolites]].<br /> | *[[MR1 Binds Vitamin Metabolites]].<br /> | ||
* '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins. | * '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins<ref>PMID:15120183</ref>. | ||
</StructureSection> | </StructureSection> | ||
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== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:11, 14 April 2016
Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.
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3D structures of MHC3D structures of MHC
Updated on 14-April-2016
ReferencesReferences
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005