Macrophage inhibitory factor: Difference between revisions
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<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene=''> | <StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene=''> | ||
== Function == | == Function == | ||
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. | '''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>. | ||
== Relevance == | == Relevance == | ||
MIF plays a role in various solid and hematologic tumors<ref>PMID:19326434</ref>. MIF is overexpressed in various tumors and is suggested to be the molecular link between chronic inflammation and cancer. MIF has a role in skin inflammation, immune response, disease, tumorigenesis and wound healing<ref>PMID:15659324</ref>. MIF has a role in Alzheimer disease and its inhibition may prevent the disease onset<ref>PMID:20200619</ref>. | MIF plays a role in various solid and hematologic tumors<ref>PMID:19326434</ref>. MIF is overexpressed in various tumors and is suggested to be the molecular link between chronic inflammation and cancer. MIF has a role in skin inflammation, immune response, disease, tumorigenesis and wound healing<ref>PMID:15659324</ref>. MIF has a role in Alzheimer disease and its inhibition may prevent the disease onset<ref>PMID:20200619</ref>. | ||
== Structural highlights == | |||
MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60. The inhibitor binds to the pro-inflammatory tautomerase site<ref>PMID:17526494</ref>. | |||
</StructureSection> | </StructureSection> | ||