Leukocyte immunoglobulin-like receptor: Difference between revisions

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*LIR-1
*LIR-1


**[[1g0x]], [[1ufu]] – hLIR ligand-binding domain human <br />
**[[1g0x]], [[1ufu]] – hLIR ligand-binding domain D1D2– human <br />
**[[1ugn]], [[1vdg]] – hLIR ligand-binding domain (mutant) <br />
**[[1ugn]], [[1vdg]] – hLIR ligand-binding domain D1D2 (mutant) <br />
**[[3kgr]], [[3rp1]] – hLIR ectodomain  <br />
**[[4ll9]] – hLIR ligand-binding domain D3D4 <br />
**[[4esk]], [[4ety]] – LIR ectodomain  - mouse<br />


*LIR-1 complexes
*LIR-1 complexes


**[[1p7q]] – hLIR ligand-binding domain + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
**[[1p7q]] – hLIR ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
**[[3d2u]] – hLIR ligand-binding domain + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
**[[3d2u]] – hLIR ligand-binding domain D1D2 + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:55, 11 April 2016


Leukocyte immunoglobulin-like receptors (LIR) or CD85 have extracellular immunoglobulin domains. LIR modulates a variety of immune cells. LIR interacts with class I MHC molecules[1].

Structure of human leukocyte immunoglobulin-like receptor ligand-binding domain (yellow) complex with class I MHC (grey), β-2 microglobulin (green) and POL polyprotein peptide (pink) (PDB entry 1p7q)

Drag the structure with the mouse to rotate

3D structures of leukocyte immunoglobulin-like receptor3D structures of leukocyte immunoglobulin-like receptor

Updated on 11-April-2016

ReferencesReferences

  1. Thomas R, Matthias T, Witte T. Leukocyte immunoglobulin-like receptors as new players in autoimmunity. Clin Rev Allergy Immunol. 2010 Apr;38(2-3):159-62. doi:, 10.1007/s12016-009-8148-8. PMID:19548123 doi:http://dx.doi.org/10.1007/s12016-009-8148-8

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman