Sandbox Reserved 426: Difference between revisions

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OCA, Lynmarie K Thompson, Student, Arash Manafirad, Allison Coutu

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	==Binding Interactions==		==Binding Interactions==
	There are three main locations where ion ligands bind to the oligonucleotide/drug complex. The key ligand is shown <scene name='48/483883/Annie_scene/1'>here</scene> in pink. Its function is to close the drug cavity, holding the anthraquinone derivative in place. It can be an Na+, ~~Mg2~~+, or ~~Ba2~~+ ion. The two other ligands, shown in cyan bind four to five nucleotides away from the drug itself. ~~Co2~~+ ions were always present at these locations in this complex and in similar complexes. Complexes that did not contain ~~Co2~~+ did not diffract. Literature states that the variable ion gives strength to the binding of the ~~Co2~~+ ions. It may be reasoned that this interaction may also behave oppositely. The binding of the ~~Co2~~+ ions may strengthen the closure of the pocket containing the drug. ~~Co2~~+ and ~~Ba2~~+ ions were found in more locations that are not shown here because they only appeared sporadically and in differing locations. Therefore, they are probably not precisely important to the function of this drug complex.		There are three main locations where ion ligands bind to the oligonucleotide/drug complex. The key ligand is shown <scene name='48/483883/Annie_scene/1'>here</scene> in pink. Its function is to close the drug cavity, holding the anthraquinone derivative in place. It can be an Na(+), Mg(2+), or Ba(2+) ion. The two other ligands, shown in cyan bind four to five nucleotides away from the drug itself. Co(2+) ions were always present at these locations in this complex and in similar complexes. Complexes that did not contain Co(2+) did not diffract. Literature states that the variable ion gives strength to the binding of the Co(2+) ions. It may be reasoned that this interaction may also behave oppositely. The binding of the Co(2+) ions may strengthen the closure of the pocket containing the drug. Co(2+) and Ba(2+) ions were found in more locations that are not shown here because they only appeared sporadically and in differing locations. Therefore, they are probably not precisely important to the function of this drug complex.