Kelch-like protein: Difference between revisions
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<StructureSection load='4ifl' size='340' side='right' caption='Human Kelch-like protein19 (Keap1) Kelch domain (dark green) complex with NRF2 Neh2 peptide (light green) (PDB code [[4ifl]])' scene=''> | <StructureSection load='4ifl' size='340' side='right' caption='Human Kelch-like protein19 (Keap1) Kelch domain (dark green) complex with NRF2 Neh2 peptide (light green) (PDB code [[4ifl]])' scene=''> | ||
== Function == | == Function == | ||
'''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to | '''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to eight such blades form a circular β-propeller domain. β-propellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>. | ||
== Disease == | == Disease == | ||
Somatic mutations in Keap1 were found in lung cancer patients. | |||
== Relevance == | == Relevance == | ||
'''KLHL19 (Keap1)''' interacts with the Neh2 peptide of NRF2. NRF2 is a regulator of antioxidant response, hence Keap1 is investigated as a drug target. | '''KLHL19 (Keap1)''' interacts with the Neh2 peptide of NRF2. NRF2 is a regulator of antioxidant response, hence Keap1 is investigated as a drug target. | ||
== Structural highlights == | == Structural highlights == | ||
The interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif<ref>PMID:16507366</ref>. | |||
</StructureSection> | </StructureSection> | ||