Isopropylmalate dehydrogenase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2ayq| PDB=2ayq  | SIZE=400| SCENE= |right|CAPTION=Isopropylmalate dehydrogenase dimer [[2ayq]] }}
-<!--
+<StructureSection load='3vl2' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+== Function ==
-Or use the four-green-boxes-button to insert scrollable text adjacent
+'''Isopropylmalate dehydrogenase''' (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate.  This reaction is a step in the biosynthesis of leucine in bacteria and fungi.  IMDH uses [[NAD]] as a cofactor.  IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation<ref>PMID:8528769</ref>.
-to a Jmol applet. Check out the other buttons as well!
--->
+== Structural highlights ==
-'''Isopropylmalate dehydrogenase''' (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate.  This reaction is a step in the biosynthesis of leucine in bacteria and fungi.  IMDH uses NAD as a cofactor.  IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
 ==3D structures of isopropylmalate dehydrogenase==
@@ Line 56: / Line 54: @@
 **[[3fig]] - MtIMDH (mutant) + Zn
 }}
+== References ==
+<references/>
 [[Category:Topic Page]]