Interleukin: Difference between revisions
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{{STRUCTURE_2nvh| PDB=2nvh | SIZE=400| SCENE= |right| CAPTION=Human interleukin-1 β chain complex with sulfate, [[2nvh]] }} | {{STRUCTURE_2nvh| PDB=2nvh | SIZE=400| SCENE= |right| CAPTION=Human interleukin-1 β chain complex with sulfate, [[2nvh]] }} | ||
== Function == | |||
'''Interleukin''' (IL) is a cytokine which functions in the immune system | '''Interleukin''' (IL) is a cytokine which functions in the immune system. IL families are denoted by numbers<ref>PMID:3277884</ref>.<br /> | ||
* '''IL-1''' is a group of 11 cytokines which regulate immune and inflammatory response. See [[Interleukin-1 beta]].<br /> | * '''IL-1''' is a group of 11 cytokines which regulate immune and inflammatory response. See [[Interleukin-1 beta]].<br /> | ||
* '''IL-2''' is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | * '''IL-2''' is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | ||
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* '''IL-36''' acts on naïve CD4+ T cells. | * '''IL-36''' acts on naïve CD4+ T cells. | ||
== Relevance == | |||
Uncontrolled activation of IL-1 is a component of of some inflammatory diseases including gout<ref>PMID:26656658</ref>.<br /> | |||
IL-8 is implicated in inflammatory lung diseases<ref>PMID:14720072</ref>.<br /> | |||
IL-10 is implicated in inflammatory bowel disease<ref>PMID:22890722</ref>.<br /> | |||
IL-10 is a potent anti-inflammatory agent<ref>PMID:22428854</ref>.<br /> | |||
IL-23 is implicated in Crohn's disease<ref>PMID:2441050</ref>.<br /> | |||
== Disease == | |||
IL deficiency results in autoimmune disease. | |||
==3D structures of interleukin== | ==3D structures of interleukin== | ||
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}} | }} | ||
== References == | |||
<references/> | |||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||