Insulin-like growth factor binding protein: Difference between revisions
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<StructureSection load='2dsp' size='340' side='right' caption=' | <StructureSection load='2dsp' size='340' side='right' caption='Insulin-like growth factor binding protein N terminal (green) complex with Insulin-like growth factor I (wheat) (PDB code [[2dsp]])' scene=''> | ||
== Function == | == Function == | ||
Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>. The N-terminal of IGFBP is the domain which binds IGF I. | Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)<ref>PMID:10605625</ref>. The N-terminal of IGFBP is the domain which binds IGF I. | ||
== Disease == | == Disease == | ||
*IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref. <br /> | *IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration<ref>PMID:23126425</ref>,<ref>PMID:9815544</ref>. <br /> | ||
*IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br /> | *IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</ref>.<br /> | ||
*IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br /> | *IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells<ref>PMID:16685432</ref>.<br /> | ||