Glycolate oxidase: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='2rdu' size=' | <StructureSection load='2rdu' size='450' side='right' caption='Human glycolate oxidase 1 complex with glyoxylate and FMN (PDB entry [[2rdu]])' scene='48/486364/Cv/1'> | ||
== Function == | == Function == | ||
'''Glycolate oxidase''' (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>. | '''Glycolate oxidase''' (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon<ref>PMID:22286136</ref>. | ||
| Line 6: | Line 6: | ||
Mutations in GOX result in isolated asymptotic hyperoxaluria type I<ref>PMID:24996905</ref>. | Mutations in GOX result in isolated asymptotic hyperoxaluria type I<ref>PMID:24996905</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The biological assembly of human glycolate oxidase 1 <scene name='48/486364/Cv/2'>homotetramer</scene>. GOX structure shows the <scene name='48/486364/Cv/3'>typical β8/α8 fold</scene> of an α-hydroxy acid oxidase and its active site contains the cofactor FMN<ref>PMID:18215067</ref>. | The biological assembly of human glycolate oxidase 1 <scene name='48/486364/Cv/2'>homotetramer</scene>. GOX structure shows the <scene name='48/486364/Cv/3'>typical β8/α8 fold</scene> of an α-hydroxy acid oxidase and its <scene name='48/486364/Cv/6'>active site contains the cofactor FMN</scene><ref>PMID:18215067</ref>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of glycolate oxidase== | ==3D structures of glycolate oxidase== | ||