Growth factor receptor-bound protein: Difference between revisions
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<StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | <StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | ||
== Function == | |||
'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | * '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | ||