Growth factor receptor-bound protein: Difference between revisions
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<StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | <StructureSection load='1bmb' size='350' side='right' caption='Structure of human Grb2 SH2 domain (grey) complex with phosphotyrosyl polypeptide (gold) (PDB entry [[1bmb]])' scene=''> | ||
== Function == | |||
'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | * '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | ||
* '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br /> | * '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br /> | ||
* '''GRB10''' and '''GRB14''' interact with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | * '''GRB10''' and '''GRB14''' interact with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | ||
== Structural highlights == | |||
Human GRB2 residue Trp121 forces the phosphotyrosyl containing ligand into a turn conformation<ref>PMID:10090780</ref>. | |||
</StructureSection> | </StructureSection> | ||
Revision as of 14:48, 16 March 2016
== Function == Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.
Structural highlightsHuman GRB2 residue Trp121 forces the phosphotyrosyl containing ligand into a turn conformation[4]. |
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3D structures of growth factor receptor-bound proteins3D structures of growth factor receptor-bound proteins
Updated on 16-March-2016
ReferencesReferences
- ↑ Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992 Aug 7;70(3):431-42. PMID:1322798
- ↑ Nadler Y, Gonzalez AM, Camp RL, Rimm DL, Kluger HM, Kluger Y. Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Ann Oncol. 2010 Mar;21(3):466-73. doi: 10.1093/annonc/mdp346. Epub 2009 Aug 28. PMID:19717535 doi:http://dx.doi.org/10.1093/annonc/mdp346
- ↑ Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H. Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action. J Biol Chem. 2003 Oct 10;278(41):39311-22. Epub 2003 Jun 3. PMID:12783867 doi:http://dx.doi.org/10.1074/jbc.M304599200
- ↑ Ettmayer P, France D, Gounarides J, Jarosinski M, Martin MS, Rondeau JM, Sabio M, Topiol S, Weidmann B, Zurini M, Bair KW. Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J Med Chem. 1999 Mar 25;42(6):971-80. PMID:10090780 doi:10.1021/jm9811007