Growth factor receptor-bound protein: Difference between revisions
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'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.<br /> | * '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br /> | ||
* '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.<br /> | * '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br /> | ||
* '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | * '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | ||
</StructureSection> | </StructureSection> | ||
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**[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | **[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | ||
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== References == | |||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||