Bone morphogenetic protein: Difference between revisions

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*Bone morphogenetic protein 9
*Bone morphogenetic protein 9


**[[1zkz]], [[4mpl]] – hBMP <br />
[[Growth differentiation factor]] 2
**[[4ycg]], [[4yci]] – BMP - mouse<br />


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Revision as of 14:16, 16 March 2016

Function

Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'[1]. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on BMP-2 see Student Projects for UMass Chemistry 423 Spring 2012-4.

Relevance

Recombinant BMP is used in oral surgery and spinal fusion.

Disease

BMP-7 is involved in chronic kidney disease[2].


Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja)

Drag the structure with the mouse to rotate

3D structures of bone morphogenetic protein3D structures of bone morphogenetic protein

Updated on 16-March-2016

Growth differentiation factor 2

ReferencesReferences

  1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
  2. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel
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