4zj8: Difference between revisions

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-'''Unreleased structure'''
-The entry 4zj8 is ON HOLD  until Paper Publication
+==Structures of the human OX1 orexin receptor bound to selective and dual antagonists==
+<StructureSection load='4zj8' size='340' side='right' caption='[[4zj8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-Authors: Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P., Renger, J.J., Rosenbaum, D.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJ8 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zjc|4zjc]]</td></tr>
-[[Category: Harrell, C.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj8 OCA], [http://pdbe.org/4zj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zj8 PDBsum]</span></td></tr>
-[[Category: Renger, J.J]]
+</table>
-[[Category: Gotter, A.L]]
+== Function ==
+[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Brautigam, C A]]
 [[Category: Clark, L]]
+[[Category: Coleman, P]]
+[[Category: Gotter, A L]]
+[[Category: Harrell, C M]]
+[[Category: Renger, J J]]
+[[Category: Rosenbaum, D M]]
 [[Category: Shao, Z]]
-[[Category: Rosenbaum, D.M]]
-[[Category: Brautigam, C.A]]
 [[Category: Yin, J]]
-[[Category: Coleman, P]]
+[[Category: Orexin]]
+[[Category: Sb674042]]
+[[Category: Signaling protein]]
+[[Category: Suvorexant]]